Is there a connection between Propylene Glycol and Diabetes?
What is Propylene Glycol?
Propylene Glycol is a clear, odorless liquid made from petroleum. It’s used as a stabilizer (to keep things held together, and keep them from evaporating), and to keep foods moist. It’s used in many of the foods that we eat, and the FDA deems it safe for human consumption.
Special Remarks on other Toxic Effects on Humans:
Acute Potential Health Effects:
- Skin: May cause mild skin irritation. It may be absorbed through the skin and cause systemic effects similar to those of ingestion.
- Eyes: May cause mild eye irritation with some immediate, transitory stinging, lacrimation, blepharospasm, and mild transient conjunctival hyperemia. There is no residual discomfort or injury once it is washed away.
- Inhalation: May cause respiratory tract irritation.
- Ingestion: It may cause gastrointestinal tract irritation.
- It may affect behavior/central nervous system(CNS depression, general anesthetic, convulsions, seizures, somnolence, stupor, muscle contraction or spasticity, coma), brain (changes in surface EEG), metabolism, blood (intravascular hemolysis, white blood cells – decreased neutrophil function), respiration (respiratory stimulation, chronic pulmonary edema, cyanosis), cardiovascular system(hypotension, bradycardia, arrhythmias, cardiac arrest), endocrine system (hypoglycemia), urinary system (kidneys), and liver.
Chronic Potential Health Effects:
- Skin: Prolonged or repeated skin contact may cause allergic contact dermatitis.
- Ingestion: Prolonged or repeated ingestion may cause hyperglycemia and may affect behavior/CNS (symptoms similar to that of acute ingestion).
- Inhalation: Prolonged or repeated inhalation may affect behavior/CNS (with symptoms similar to ingestion), and spleen
According to the World Health Organization, the acceptable dietary intake of Propylene Glycol is 25 mg (25mg = 0.0009 oz) of propylene glycol for every kilogram (kg) (1kg = 2lb) of body weight.
According to the FDA’s Important Drug Warnings on some medications which include Propylene Glycol the warnings discuss the inability of of infants, children under the age of 4 years, and pregnant women as well as those with kidney problems to process and eliminate Propylene Glycol which leads to accumulation and potential adverse effects
Kaletra oral solution contains the ingredients alcohol and propylene glycol. Premature babies may be at increased risk for health problems because they have a decreased ability to eliminate propylene glycol; this could lead to adverse events such as serious heart, kidney, or breathing problems.